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Author Abiona, Olubukola M. ♦ Marraudino, Marilena ♦ Peretto, Paolo ♦ Stampar, Mojca ♦ Lin, Weihong ♦ Schellino, Roberta ♦ Oboti, Livio ♦ Trova, Sara ♦ Harris, Natalie R.
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Frontiers Media S.A.
File Format HTM / HTML
Date Created 2017-05-23
Copyright Year ©2017
Language English
Subject Domain (in LCC) RC321-571 ♦ QM1-695
Subject Keyword Neuropsychiatry ♦ Biological psychiatry ♦ Neurosciences ♦ Vomeronasal system ♦ Sensory adaptation ♦ Human anatomy ♦ Science ♦ Internal medicine ♦ Neurogenesis ♦ Puberty ♦ Sexual signals ♦ Medicine
Abstract The vomeronasal system (VNS) is specialized in the detection of salient chemical cues triggering social and neuroendocrine responses. Such responses are not always stereotyped, instead, they vary depending on age, sex, and reproductive state, yet the mechanisms underlying this variability are unclear. Here, by analyzing neuronal survival in the first processing nucleus of the VNS, namely the accessory olfactory bulb (AOB), through multiple bromodeoxyuridine birthdating protocols, we show that exposure of female mice to male soiled bedding material affects the integration of newborn granule interneurons mainly after puberty. This effect is induced by urine compounds produced by mature males, as bedding soiled by younger males was ineffective. The granule cell increase induced by mature male odor exposure is not prevented by pre-pubertal ovariectomy, indicating a lesser role of circulating estrogens in this plasticity. Interestingly, the intake of adult male urine-derived cues by the female vomeronasal organ increases during puberty, suggesting a direct correlation between sensory activity and AOB neuronal plasticity. Thus, as odor exposure increases the responses of newly born cells to the experienced stimuli, the addition of new GABAergic inhibitory cells to the AOB might contribute to the shaping of vomeronasal processing of male cues after puberty. Consistently, only after puberty, female mice are capable to discriminate individual male odors through the VNS.
ISSN 16625129
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2017-05-01
e-ISSN 16625129
Journal Frontiers in Neuroanatomy
Volume Number 11

Source: Directory of Open Access Journals (DOAJ)