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Author Elebas, Nicolas ♦ Edoutremer, Suzette ♦ Eribot, Jérôme ♦ Quoc, Emmanuel Ebui ♦ Emilleret, Chantal ♦ Equenech'du, Nicole ♦ Eaushana, Yonane ♦ Egrantyn, Alexej
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Frontiers Media S.A.
File Format HTM / HTML
Date Created 2014-05-22
Copyright Year ©2012
Language English
Subject Domain (in LCC) RC321-571 ♦ QM1-695
Subject Keyword Neuropsychiatry ♦ Biological psychiatry ♦ Higher mammals ♦ Neurosciences ♦ Human anatomy ♦ Strabismus ♦ Science ♦ Visual interhemispheric integration ♦ Internal medicine ♦ Cerebral Asymmetry ♦ Medicine
Abstract In the mammalian primary visual cortex, the corpus callosum contributes to the unification of the visual hemifields that project to the two hemispheres. Its development depends on visual experience. When the latter is abnormal, callosal connections must undergo dramatic anatomical and physiological changes. However, such data are sparse and incomplete. Thus, little is known about the consequences of abnormal postnatal visual experience on the development of callosal connections and their role in unifying representation of the two hemifields. Here, the effects of early unilateral convergent strabismus (a model of abnormal visual experience) were fully characterized with respect to the development of the callosal connections in cat visual cortex, an experimental model for humans. Electrophysiological responses and 3D reconstruction of single callosal axons show that abnormally asymmetrical callosal connections develop after unilateral convergent strabismus, resulting from an extension of axonal branches of specific orders in the hemisphere ipsilateral to the deviated eye and a decreased number of nodes and terminals in the other (ipsilateral to the non deviated eye). Furthermore this asymmetrical organization prevents the establishment of a unifying representation of the two visual hemifields. As a general rule, we suggest that crossed and uncrossed retino-geniculo-cortical pathways contribute in succession to the development of the callosal maps in visual cortex.
ISSN 16625129
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2012-01-01
e-ISSN 16625129
Journal Frontiers in Neuroanatomy
Volume Number 5


Source: Directory of Open Access Journals (DOAJ)