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Author Xu, Tao ♦ Hwang, William L. ♦ Su, Fei ♦ Chakrabarty, Krishnendu
Source ACM Digital Library
Content type Text
Publisher Association for Computing Machinery (ACM)
File Format PDF
Copyright Year ©2007
Language English
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Physical design automation ♦ Biochips ♦ Droplets ♦ Microfluidics
Abstract Microfluidics-based biochips, also referred to as lab-on-a-chip, are devices that integrate fluid-handling functions such as sample preparation, analysis, separation, and detection. This emerging technology combines electronics with biology to open new application areas such as point-of-care diagnosis, on-chip DNA analysis, and automated drug discovery. We propose a design automation method for pin-constrained biochips that manipulate nanoliter volumes of discrete droplets on a microfluidic array. In contrast to the direct-addressing scheme that has been studied thus far in the literature, we assign a small number of independent control pins to a large number of electrodes in the biochip, thereby reducing design complexity and product cost. The design procedure relies on a droplet-trace-based array partitioning scheme and an efficient pin assignment technique, referred to as the “Connect-5 algorithm.” The proposed method is evaluated using a set of multiplexed bioassays.
ISSN 15504832
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2007-11-01
Publisher Place New York
e-ISSN 15504840
Journal ACM Journal on Emerging Technologies in Computing Systems (JETC)
Volume Number 3
Issue Number 3


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Source: ACM Digital Library