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Author Karpinska, Joanna
Source J-STAGE
Content type Text
Publisher The Japan Society for Analytical Chemistry
Language English
Abstract The use of derivative UV-spectrophotometry is proposed for the simultaneous quantification of promazine hydrochloride in the presence of sulfoxide, and vice versa. For this purpose, mathematical parameters were established for generating derivative spectra of analytes. The determination of promazine was made using the first-order derivative (Δλ = 10 nm, second polynomial degree) at 268 nm. The quantification of sulfoxide was achieved by applying third-derivative spectra (Δλ = 14 nm, sixth polynomial degree) based on measurements of the amplitude at 342 - 344 nm. An elaborated method was successfully used to determine analytes in commercial promazine pharmaceuticals. The obtained results agreed well with those obtained by the HPLC method.
ISSN 09106340
Learning Resource Type Article
Publisher Date 2001-01-01
e-ISSN 13482246
Journal Analytical Sciences(analsci)
Volume Number 17
Issue Number 2
Page Count 5
Starting Page 249
Ending Page 253


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