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Author Liu, Jun ♦ Li, Qingwen ♦ Yu, Yadong ♦ Fang, Xiang
Source J-STAGE
Content type Text
Publisher The Japan Society for Analytical Chemistry
Language English
Abstract Dopamine may show some biological activities in antitumor and cell apoptosis. Herein, we attempted to employ UV-Vis, CD, and electrochemical methods to investigate the interaction between DNA and dopamine. Both the spectroscopic and electrochemical evidence indicated that dopamine, which was a cation, could interact with polyanion DNA. However, this kind of interaction, mainly by a static electronic force, did not result in any damage of the DNA structure. This situation was quite different when Cu ion was added to the dopamine-DNA system; an obvious change in the color of the solution and in the spectra of UV-Vis and CD showed that some chemical changes occurred in this system, and that the DNA native structure was destroyed. The results of gel electrophores further revealed that DNA might be broken into small segments by dopamine in the presence of Cu ion. The possible reaction mechanisms are discussed.
ISSN 09106340
Learning Resource Type Article
Publisher Date 2003-01-01
e-ISSN 13482246
Journal Analytical Sciences(analsci)
Volume Number 19
Issue Number 8
Page Count 4
Starting Page 1099
Ending Page 1102


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