### Spectrophotometric Determination of Certain Vicinal Dihydroxybenzene Derivatives in Pharmaceutical PreparationsSpectrophotometric Determination of Certain Vicinal Dihydroxybenzene Derivatives in Pharmaceutical Preparations

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 Author Gowda, Babu G. ♦ Melwanki, Mahaveer B. ♦ Seetharamappa, Jaldappa Source J-STAGE Content type Text Publisher The Japan Society for Analytical Chemistry Language English
 Abstract A simple, rapid and sensitive spectrophotometric method for the assay of certain adrenergic drugs, [pyrocatechol (PC), levodopa (LD), methyldopa (MD) and dopamine (DP)] is described. The method involves the oxidation of o-dihydroxybenzene derivatives by $K_{2}CrO_{4}$ followed by oxidative coupling with sulfanilic acid (SPA), leading to the formation of a red or violet colored product having maximum absorbance at 490 - 495 nm for LD, MD and DP or at 560 nm for PC. This method has been successfully applied to the determination of LD, MD and DP in tablets and injections of pharmaceutical preparation. The common excipients do not interfere with the proposed method. A statistical comparison of these results with those of a reported method shows good agreement and indicates no significant difference in precision. ISSN 09106340 Learning Resource Type Article Publisher Date 2001-01-01 e-ISSN 13482246 Journal Analytical Sciences(analsci) Volume Number 17 Issue Number 4 Page Count 2 Starting Page 533 Ending Page 534