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Author Gowda, Babu G. ♦ Melwanki, Mahaveer B. ♦ Seetharamappa, Jaldappa
Source J-STAGE
Content type Text
Publisher The Japan Society for Analytical Chemistry
Language English
Abstract A simple, rapid and sensitive spectrophotometric method for the assay of certain adrenergic drugs, [pyrocatechol (PC), levodopa (LD), methyldopa (MD) and dopamine (DP)] is described. The method involves the oxidation of o-dihydroxybenzene derivatives by $K_{2}CrO_{4}$ followed by oxidative coupling with sulfanilic acid (SPA), leading to the formation of a red or violet colored product having maximum absorbance at 490 - 495 nm for LD, MD and DP or at 560 nm for PC. This method has been successfully applied to the determination of LD, MD and DP in tablets and injections of pharmaceutical preparation. The common excipients do not interfere with the proposed method. A statistical comparison of these results with those of a reported method shows good agreement and indicates no significant difference in precision.
ISSN 09106340
Learning Resource Type Article
Publisher Date 2001-01-01
e-ISSN 13482246
Journal Analytical Sciences(analsci)
Volume Number 17
Issue Number 4
Page Count 2
Starting Page 533
Ending Page 534


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