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Author Peng, Xiangwen ♦ He, Quanze ♦ Li, Guobao ♦ Ma, Jinmin ♦ Zhong, Tao P.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword APPLIED LIFE SCIENCES ♦ CELL PROLIFERATION ♦ HEART ♦ INHIBITION ♦ INJURIES ♦ MOLECULES ♦ PHOSPHOTRANSFERASES ♦ REGENERATION ♦ SERINE ♦ THREONINE
Abstract P-21 activated kinases, or PAKs, are serine–threonine kinases that play important roles in diverse heart functions include heart development, cardiovascular development and function in a range of models; however, the mechanisms by which PAKs mediate heart regeneration are unknown. Here, we demonstrate that PAK2 and PAK4 expression is induced in cardiomyocytes and vessels, respectively, following zebrafish heart injury. Inhibition of PAK2 and PAK4 using a specific small molecule inhibitor impedes cardiomyocyte proliferation/dedifferentiation and cardiovascular regeneration, respectively. Cdc42 is specifically expressed in the ventricle and may function upstream of PAK2 but not PAK4 under normal conditions and that cardiomyocyte proliferentation during heart regeneration relies on Rac1-mediated activation of Pak2. Our results indicate that PAKs play a key role in heart regeneration.
ISSN 0006291X
Educational Use Research
Learning Resource Type Article
Publisher Date 2016-04-15
Publisher Place United States
Journal Biochemical and Biophysical Research Communications
Volume Number 472
Issue Number 4


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