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Author Vora, Sheetal S. ♦ Syverson, Grant D. ♦ Nocton, James J. ♦ Bengtson, Christine E.
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher BioMed Central
File Format HTM / HTML
Date Created 2010-04-30
Copyright Year ©2010
Language English
Subject Domain (in LCC) RJ1-570 ♦ RC925-935
Subject Keyword Pediatrics ♦ Internal medicine ♦ Medicine ♦ Diseases of the musculoskeletal system ♦ Specialties of internal medicine
Abstract Abstract Background No consensus evidence-based guidelines for the routine laboratory monitoring of children with JIA receiving non-steroidal anti-inflammatory drugs (NSAIDs) exist. The purpose of this study is to evaluate the clinical utility of routine laboratory monitoring of hemoglobin, transaminases, blood urea nitrogen, serum creatinine, and urinalysis in patients with juvenile idiopathic arthritis (JIA) receiving NSAIDs. Methods The medical records of 91 children with JIA followed between 1996 and 2006 were retrospectively reviewed for laboratory results and clinically significant adverse effects attributed to NSAID use. Laboratory abnormalities were documented, with potential adverse clinical sequelae, including if NSAID use was discontinued. Results Abnormal laboratory results were recorded for 24 of 91 patients. Nearly all abnormalities were mild and not associated with adverse clinical sequelae. All patients but one continued to receive NSAID therapy after the abnormality was detected. Conclusions Although detection of abnormal laboratory values occurred while on NSAIDs, these abnormalities did not correlate with adverse clinical signs and symptoms. The routine monitoring of laboratory tests in asymptomatic children treated with NSAIDs is of questionable utility.
ISSN 15460096
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2010-04-01
e-ISSN 15460096
Journal Pediatric Rheumatology Online Journal
Volume Number 8
Issue Number 1
Starting Page 11


Source: Directory of Open Access Journals (DOAJ)