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Author Evidente, Virgilio Gerald H. ♦ Caviness, John N. ♦ Choi, Sunah
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Korean Movement Disorders Society
File Format PDF
Date Created 2016-04-22
Copyright Year ©2010
Language English
Subject Domain (in LCC) RC321-571 ♦ RC346-429
Subject Keyword Neuropsychiatry ♦ Biological psychiatry ♦ Neurosciences ♦ Diseases of the nervous system ♦ Internal medicine ♦ Dementia ♦ White matter lesions ♦ Medicine ♦ Parkinson’s disease ♦ Neurology
Abstract Cerebral white matter lesions (CWMLs) have been suggested to be associated with an increased risk of dementia, disability, and death. CWMLs are more common in individuals with Alzheimer’s disease (AD) than in normal elderly individuals of comparable age. Only a few studies have been done to determine whether CWMLs may influence cognitive decline in Parkinson’s disease (PD). Fully developed PD with concurrent AD was reported to likely cause impaired cognition in spite of accumulating evidence suggesting that PD with dementia (PDD) is more closely associated with Lewy body (LB) pathology. Currently, contradictory data on the neuropathology of dementia in PD require further prospective clinicopathological studies in larger cohorts to elucidate the impact of AD and α-synuclein (SCNA) pathologies on the cognitive status in these disorders. Previous reports did not suggest CWMLs to be associated with an increased risk of PDD. After adjusting for age at death, age at onset of PD, and duration of PD, our recent study investigating CWMLs in PDD via autopsy has shown a positive correlation between the burden of CWMLs and PDD. The frequent co-existence of both LB and AD lesions suggests that both pathologies independently or synergistically contribute to both movement disorders and cognitive impairment. The individual and cumulative burden of CWMLs, LB lesions, and AD lesions may synergistically contribute to cognitive decline in LB disorders such as PDD.
ISSN 2005940X
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2010-05-01
e-ISSN 2005940X
Journal Journal of Movement Disorders
Volume Number 3
Issue Number 1
Page Count 5
Starting Page 6
Ending Page 10


Source: Directory of Open Access Journals (DOAJ)