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Author Sohn, Young Ho ♦ Shin, Haewon
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Korean Movement Disorders Society
File Format PDF
Date Created 2016-04-22
Copyright Year ©2009
Language English
Subject Domain (in LCC) RC321-571 ♦ RC346-429
Subject Keyword Neuropsychiatry ♦ Homocysteine ♦ Biological psychiatry ♦ Neurosciences ♦ Diseases of the nervous system ♦ Vitamin B ♦ Internal medicine ♦ Medicine ♦ Parkinson’s disease ♦ Neurology
Abstract Background: Plasma homocysteine (Hcy) levels are increased in patients with Parkinson’s disease (PD) undergoing levodopa treatment. We measured the Hcy levels in PD patients and assessed the relationship between Hcy level and features of PD, cognitive function and vitamin B status. Methods: Concentrations of Hcy, vitamin B12 and folate were measured in 33 PD patients and 41 normal control individuals. Mini-mental Status Examination (MMSE) was assessed in all subjects. In PD patients, Hoehn & Yahr stage and Unified Parkinson Disease Rating Scale (UPDRS) motor scores were also examined. Results: Plasma Hcy levels were lower in PD patients than in control individuals. Hcy level was inversely correlated with vitamin B12 and folate levels in the PD group but not in control individuals. Age, symptom duration, UPDRS motor scores, MMSE score, levodopa dose and duration of treatment did not differ between patients with Hcy >14 μmol/L and those with Hcy <14 μmol/L. Conclusions: Plasma Hcy levels were increased in PD patients with levodopa treatment and were related to vitamin B level. These results indicate that vitamin supplementation may be beneficial in levodopa-treated PD patients, although hyperhomocysteinemia did not affect the motor and cognitive status of PD patients.
ISSN 2005940X
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2009-05-01
e-ISSN 2005940X
Journal Journal of Movement Disorders
Volume Number 2
Issue Number 1
Page Count 4
Starting Page 33
Ending Page 36


Source: Directory of Open Access Journals (DOAJ)