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Author Durmus, Hasan ♦ Durmazel, Selen ♦ Üzer, Aysem ♦ Gökdere, Bahar ♦ Erçag, Erol ♦ Apak, Resat
Source J-STAGE
Content type Text
Publisher The Japan Society for Analytical Chemistry
Language English
Subject Keyword Forensic science ♦ (aminoalkyl)indole ♦ synthetic cannabimimetics ♦ Ehrlich reaction ♦ p-dimethylaminobenzaldehyde ♦ colorimetric detection
Abstract Cannabis is an important industrial plant, in addition to its illicit drug use. Compound $Δ^{9}-THC$ $(Δ^{9}-tetrahydrocannabinol)$ is mainly responsible for the hallucinogenic effect on humans. The aminoalkylindole group cannabimimetics targets at the same physiological receptors to mimic the analgesic effects of $Δ^{9}-THC.$ Since there is no reliable colorimetric test to detect these synthetic cannabimimetics on site, a simple colorimetric assay for (aminoalkyl)indole group-containing drugs was developed, based on the silica/sulfuric acid-catalyzed Ehrlich reaction of (aminoalkyl)indoles with p-dimethylaminobenzaldehyde. The electrophilic substitution reaction of indoles with carbonyl compounds resulting in the formation of bis(indolyl)alkanes in an acid-catalyzed reaction has been used for the first time for their spectrophotometric determination by color change from yellow to purple/blue. The method was statistically validated against liquid chromatography tandem mass spectrometry, and applied to certain (aminoalkyl)indole derivatives, with 0.5 – 2.5 μg $mL^{−1}$ detection limits for AM-2201, JWH-081, MAM-2201, JWH-018, JWH-210, JWH-122, 5F-PB-22 and XLR-11.
ISSN 09106340
Learning Resource Type Article
Publisher Date 2018-12-10
e-ISSN 13482246
Journal Analytical Sciences(analsci)
Volume Number 34
Issue Number 12
Page Count 7
Starting Page 1419
Ending Page 1425


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