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Author Kumar, Pradesh ♦ Ravi, Rajeev ♦ Sundar, Gaurav ♦ Shiach, Caroline
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword APPLIED LIFE SCIENCES ♦ RADIOLOGY AND NUCLEAR MEDICINE ♦ ABSORPTION SPECTROSCOPY ♦ ANTICOAGULANTS ♦ DISEASES ♦ DOSES ♦ PATIENTS ♦ PHARMACOLOGY ♦ THROMBIN ♦ VITAMIN K ♦ X-RAY SPECTROSCOPY
Abstract The direct oral anticoagulants (DOACs) have emerged as a good alternative for the treatment of thromboembolic diseases, and their use in clinical practice is increasing rapidly. The DOACs act by blocking the activity of one single step in the coagulation cascade. These drugs act downstream in the common pathway of the coagulation cascade by directly antagonising the action of thrombin or factor Xa. The development of DOACs represents a paradigm shift from the oral vitamin K antagonists such as warfarin. This article aims to describe the properties of the currently available DOACs including pharmacology and dosing. We also address the strategies for periprocedural management and reversal of anticoagulation of patients treated with these agents.
ISSN 01741551
Educational Use Research
Learning Resource Type Article
Publisher Date 2017-03-15
Publisher Place United States
Journal Cardiovascular and Interventional Radiology
Volume Number 40
Issue Number 3


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