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Author Xie, Yunhe ♦ Bentefour, El Hassane ♦ Janssens, Guillaume ♦ Smeets, Julien ♦ Vander Stappen, François ♦ Hotoiu, Lucian ♦ Yin, Lingshu ♦ Dolney, Derek ♦ Avery, Stephen ♦ O.'Grady, Fionnbarr ♦ Prieels, Damien ♦ McDonough, James ♦ Solberg, Timothy D. ♦ Lustig, Robert A. ♦ Lin, Alexander ♦ Teo, Boon-Keng K.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIOLOGY AND NUCLEAR MEDICINE ♦ IN VIVO ♦ PROTON BEAMS ♦ RADIOTHERAPY ♦ VERIFICATION
Abstract Purpose: To report the first clinical results and value assessment of prompt gamma imaging for in vivo proton range verification in pencil beam scanning mode. Methods and Materials: A stand-alone, trolley-mounted, prototype prompt gamma camera utilizing a knife-edge slit collimator design was used to record the prompt gamma signal emitted along the proton tracks during delivery of proton therapy for a brain cancer patient. The recorded prompt gamma depth detection profiles of individual pencil beam spots were compared with the expected profiles simulated from the treatment plan. Results: In 6 treatment fractions recorded over 3 weeks, the mean (± standard deviation) range shifts aggregated over all spots in 9 energy layers were −0.8 ± 1.3 mm for the lateral field, 1.7 ± 0.7 mm for the right-superior-oblique field, and −0.4 ± 0.9 mm for the vertex field. Conclusions: This study demonstrates the feasibility and illustrates the distinctive benefits of prompt gamma imaging in pencil beam scanning treatment mode. Accuracy in range verification was found in this first clinical case to be better than the range uncertainty margin applied in the treatment plan. These first results lay the foundation for additional work toward tighter integration of the system for in vivo proton range verification and quantification of range uncertainties.
ISSN 03603016
Educational Use Research
Learning Resource Type Article
Publisher Date 2017-09-01
Publisher Place United States
Journal International Journal of Radiation Oncology, Biology and Physics
Volume Number 99
Issue Number 1


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