### Extended and Robust Protein Sequence Annotation over Conservative Nonhierarchical Clusters: The Case Study of the ABC TransportersExtended and Robust Protein Sequence Annotation over Conservative Nonhierarchical Clusters: The Case Study of the ABC Transporters

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 Author Piovesan, Damiano ♦ Profiti, Giuseppe ♦ Martelli, Pier Luigi ♦ Fariselli, Piero ♦ Casadio, Rita Source ACM Digital Library Content type Text Publisher Association for Computing Machinery (ACM) File Format PDF Copyright Year ©2013 Language English
 Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science Subject Keyword ABC transporters ♦ ATP-binding domain ♦ Protein functional annotation ♦ Cross-genome comparison ♦ Distantly related homolog ♦ Profile HMMs Abstract Genome annotation is one of the most important issues in the genomic era. The exponential growth rate of newly sequenced genomes and proteomes urges the development of fast and reliable annotation methods, suited to exploit all the information available in curated databases of protein sequences and structures. To this aim we developed BAR+, the Bologna Annotation $Resource.^{1}$ The basic notion is that sequences with high identity value to a counterpart can inherit the same function/s and structure, if available. As a case study we describe how the ATP-binding domain of the ABC transporters can be found and modeled in over 30,000 new sequences not annotated before. We also mapped into BAR+ all the ABC transporters listed in the Transporter Classification $DataBase^{2}$ and found that within our environment annotation could be extended to another 256,866 sequences. ISSN 15504832 Age Range 18 to 22 years ♦ above 22 year Educational Use Research Education Level UG and PG Learning Resource Type Article Publisher Date 2013-11-01 Publisher Place New York e-ISSN 15504840 Journal ACM Journal on Emerging Technologies in Computing Systems (JETC) Volume Number 9 Issue Number 4 Page Count 8 Starting Page 1 Ending Page 8

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Source: ACM Digital Library