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Author Toyama, Yoshiro ♦ Suzuki-Toyota, Fumie ♦ Maekawa, Mamiko ♦ Ito, Chizuru ♦ Toshimori, Kiyotaka
Source J-STAGE
Content type Text
Publisher International Society of Histology and Cytology
Language English
Abstract Either a 20 or 200μg/kg body weight/injection of bisphenol A (BPA) was subcutaneously administered to adult mice and rats for 6 days, and the effects on the testes were investigated by electron and light microscopy. Abnormalities were observed in the spermatids: acrosomal vesicles, acrosomal caps, acrosomes and nuclei of the spermatids were severely deformed. The ectoplasmic specialization between the Sertoli cell and spermatids were also affected: incomplete specialization, redundant ectopic specialization and aplasia were observed. Rats and mice responded similarly to BPA. There were no dose dependencies between the 20- and 200μg/kg body weight/injection groups. The ectoplasmic specialization between adjoining Sertoli cells, or blood-testis barrier, was not affected. Since similar adverse effects were observed when adult mice were treated with β-estradiol 3-benzoate, the effects of BPA reported here seem to reflect the estrogenic effects on the testes. Animals kept for an additional two months after cessation of the administration were shown to be fertile and the testes showed normal histology, indicating that the adverse effects were transitory.
ISSN 09149465
Learning Resource Type Article
Publisher Date 2004-01-01
e-ISSN 13491717
Journal Archives of Histology and Cytology(aohc)
Volume Number 67
Issue Number 4
Page Count 9
Starting Page 373
Ending Page 381


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