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Author Jian ding ♦ Yan kang ♦ Yuqin fan ♦ Qi chen
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Bioscientifica
File Format HTM / HTML
Date Created 2018-01-30
Copyright Year ©2017
Language English
Subject Domain (in LCC) RC648-665
Subject Keyword Clinical endocrinology ♦ Diseases of the endocrine glands ♦ Nifedipine ♦ Pregnancy ♦ Internal medicine ♦ Medicine ♦ Preeclampsia ♦ Hypertension ♦ Resveratrol ♦ Specialties of internal medicine
Abstract Objective: Preeclampsia (PE) is a complication affecting pregnant women worldwide, which usually manifests as severe maternal hypertension. Resveratrol (RESV), a naturally existing polyphenol, is known to exhibit beneficial effects in cardiovascular disease including hypertension. We evaluated the outcome of treatment combining oral nifedipine (NIFE) and RESV against PE. Design and methods: Using a randomized group assignment, 400 PE patients were enrolled and received oral treatments of either NIFE + RESV or NIFE + placebo. Primary endpoints were defined as time to control blood pressure and time before a new hypertensive crisis. Secondary endpoints were defined as the number of doses needed to control blood pressure, maternal and neonatal adverse effects. Results: Compared with the NIFE + placebo group, the time needed to control blood pressure was significantly reduced in NIFE + RESV group, while time before a new hypertensive crisis was greatly delayed in NIFE + RESV group. The number of treatment doses needed to control blood pressure was also categorically lower in NIFE + RESV group. No differences in maternal or neonatal adverse effects were observed between the two treatment groups. Conclusion: Our data support the potential of RESV as a safe and effective adjuvant of oral NIFE to attenuate hypertensive symptoms among PE patients.
ISSN 20493614
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2017-10-01
e-ISSN 20493614
Journal Endocrine Connections
Volume Number 6
Issue Number 8
Page Count 6
Starting Page 595
Ending Page 600


Source: Directory of Open Access Journals (DOAJ)