Thumbnail
Access Restriction
Open

Author Hermens, J. ♦ Busser, F. ♦ Leeuwangh, P. ♦ Musch, A.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT. ♦ ENVIRONMENTAL SCIENCES ♦ BIOLUMINESCENCE ♦ INHIBITION ♦ ORGANIC COMPOUNDS ♦ STRUCTURE-ACTIVITY RELATIONSHIPS ♦ TOXICITY ♦ COMPUTERS ♦ PHOTOSYNTHETIC BACTERIA ♦ WATER POLLUTION ♦ LUMINESCENCE ♦ POLLUTION ♦ Chemicals Metabolism & Toxicology- Microorganisms- (-1987) ♦ Environment, Aquatic- Chemicals Monitoring & Transport- (-1989)
Abstract Quantitative structure-activity relationships were calculated for the inhibition of bioluminescence of Photobacterium phosphoreum by 22 nonreactive organic chemicals. The inhibition was measured using the Microtox test and correlated with the partition coefficient between n-octanol and water (Poct), molar refractivity (MR), and molar volume (MW/d). At log Poct less than 1 and greater than 3, deviations from linearity were observed. Introduction of MR and MW/d improved the quality of the relationships. The influences of MR or MW/d may be related with an interaction of the tested chemicals to the enzyme system which produces the light emission. The sensitivity of the Microtox test to the 22 tested compounds is comparable to a 14-day acute mortality test with guppies for chemicals with log Poct less than 4. The inhibition of bioluminescence by a mixture of the tested compounds was slightly less than was expected in case of concentration addition. The Microtox test can give a good estimate of the total aspecific minimum toxicity of polluted waters. When rather lipophilic compounds or pollutants with more specific modes of action are present, this test will underestimate the toxicity to other aquatic life.
Educational Use Research
Learning Resource Type Article
Publisher Date 1985-02-01
Publisher Place United States
Journal Ecotoxicol. Environ. Saf.
Volume Number 1
Organization Univ. of Utrecht, Netherland


Open content in new tab

   Open content in new tab