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Author Sparks, Steven M. ♦ Bickett, David M. ♦ Carter, H. Luke ♦ Clancy, Daphne C. ♦ Dickerson, Scott H. ♦ Dwornik, Kate A. ♦ Garrido, Dulce M. ♦ Golden, Pamela L. ♦ Nolte, Robert T. ♦ Sheckler, Lauren R. ♦ Tavares, Francis X. ♦ Wang, Liping ♦ Weiel, James E.
Sponsorship USDOE
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword BASIC BIOLOGICAL SCIENCES ♦ GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE ♦ AMINO ACIDS ♦ CARBOXYLIC ACIDS ♦ DIABETES MELLITUS ♦ GLYCOGEN ♦ IN VITRO ♦ INHIBITION ♦ OPTIMIZATION ♦ PHOSPHOTRANSFERASES ♦ RESIDUES
Abstract Optimization of the amino acid residue within a series of anthranilimide-based glycogen phosphorylase inhibitors is described. These studies culminated in the identification of anthranilimides 16 and 22 which displayed potent in vitro inhibition of GPa in addition to reduced inhibition of CYP2C9 and excellent pharmacokinetic properties.
ISSN 0960894X
Educational Use Research
Learning Resource Type Article
Publisher Date 2009-05-15
Publisher Place United States
Journal Bioorg. Med. Chem. Lett.
Volume Number 19
Issue Number 3
Organization Argonne National Lab. (ANL), Argonne, IL (United States)


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