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Author Berry, J. P. ♦ Galle, P.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIOLOGY AND NUCLEAR MEDICINE ♦ AIDS ♦ CHEMOTHERAPY ♦ ANTIBIOTICS ♦ SUBCELLULAR DISTRIBUTION ♦ AIDS VIRUS ♦ ANTIMONY ♦ DOSE-RESPONSE RELATIONSHIPS ♦ ELECTRON MICROPROBE ANALYSIS ♦ LYSOSOMES ♦ MACROPHAGES ♦ RATS ♦ TUNGSTEN ♦ ANIMAL CELLS ♦ ANIMALS ♦ ANTI-INFECTIVE AGENTS ♦ CELL CONSTITUENTS ♦ CHEMICAL ANALYSIS ♦ CONNECTIVE TISSUE CELLS ♦ DISEASES ♦ DISTRIBUTION ♦ DRUGS ♦ ELEMENTS ♦ IMMUNE SYSTEM DISEASES ♦ INFECTIOUS DISEASES ♦ MAMMALS ♦ METALS ♦ MICROANALYSIS ♦ MICROORGANISMS ♦ ORGANOIDS ♦ PARASITES ♦ PHAGOCYTES ♦ RODENTS ♦ SOMATIC CELLS ♦ THERAPY ♦ TRANSITION ELEMENTS ♦ VERTEBRATES ♦ VIRAL DISEASES ♦ VIRUSES ♦ Medicine- External Radiation in Diagnostics- (1980-)
Abstract The anti-viral drug HPA-23 (ammonium 21-tungsto-9-antimonate) has been proposed for use in the combat against AIDS. The two elements tungsten (W) and antimony (Sb) in the molecule enable the intracellular localization and possible breakdown of the product to be studied using electron probe microanalysis methods. Such studies have been carried out after intravenous injection of different doses of HPA-23 in the rat followed by removal of the liver, kidney, thymus, spleen, bone marrow, and lung. HPA-23 was concentrated in the lysosomes and localized in the macrophages of different tissues (thymus, spleen, and bone marrow). The W/Sb ratio was identical in these macrophages. This localization is perhaps relevant to the mechanism of action of HPA-23.
ISSN 00144800
Educational Use Research
Learning Resource Type Article
Publisher Date 1990-12-01
Publisher Place United States
Journal Experimental and Molecular Pathology
Volume Number 53
Issue Number 3


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