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Author Begolly, Sage ♦ Shrager, Peter G. ♦ Olschowka, John A. ♦ Williams, Jacqueline P. ♦ O.'Banion, M. Kerry
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIOLOGY AND NUCLEAR MEDICINE ♦ ELECTRON MICROSCOPY ♦ FRACTIONATED IRRADIATION ♦ FRACTIONATION ♦ GY RANGE 01-10 ♦ GY RANGE 10-100 ♦ MICE ♦ NERVE CELLS ♦ RADIOTHERAPY ♦ SIDE EFFECTS
Abstract Purpose: To determine the late effects of fractionated versus single-dose cranial radiation on murine white matter. Methods and Materials: Mice were exposed to 0 Gy, 6 × 6 Gy, or 1 × 20 Gy cranial irradiation at 10 to 12 weeks of age. Endpoints were assessed through 18 months from exposure using immunohistochemistry, electron microscopy, and electrophysiology. Results: Weight gain was temporarily reduced after irradiation; greater loss was seen after single versus fractionated doses. Oligodendrocyte progenitor cells were reduced early and late after both single and fractionated irradiation. Both protocols also increased myelin g-ratio, reduced the number of nodes of Ranvier, and promoted a shift in the proportion of small, unmyelinated versus large, myelinated axon fibers. Conclusions: Fractionation does not adequately spare normal white matter from late radiation side effects.
ISSN 03603016
Educational Use Research
Learning Resource Type Article
Publisher Date 2016-10-01
Publisher Place United States
Journal International Journal of Radiation Oncology, Biology and Physics
Volume Number 96
Issue Number 2


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