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Author Hamilton, J. C. ♦ Donaldson, W. E.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT. ♦ ENZYMES ♦ BIOSYNTHESIS ♦ MERCURY ♦ BIOLOGICAL EFFECTS ♦ CARBON 14 ♦ CHICKENS ♦ METABOLIC ACTIVATION ♦ METABOLISM ♦ STIMULATION ♦ ANIMALS ♦ BETA DECAY RADIOISOTOPES ♦ BETA-MINUS DECAY RADIOISOTOPES ♦ BIRDS ♦ CARBON ISOTOPES ♦ ELEMENTS ♦ EVEN-EVEN NUCLEI ♦ FOWL ♦ ISOTOPES ♦ LIGHT NUCLEI ♦ METALS ♦ NUCLEI ♦ RADIOISOTOPES ♦ SYNTHESIS ♦ VERTEBRATES ♦ YEARS LIVING RADIOISOTOPES 560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
Abstract Broilers were fed control or biotin-deficient diets based upon glucose and casein starting at day-old. At 7 days, one-half the chicks fed the biotin-deficient diet were administered 200 ppm Hg (as HgCl/sub 2/) continuously in the drinking water, while the remaining biotin-deficient chicks and the control chicks continued to receive tap water. At 4 weeks, hepatic fatty acid synthetse (FAS) and acetyl-CoA carboxylase (ACC) activities and in vivo lipogenesis from /sup 14/C-acetate were measured in randomly selected chicks from each of the 3 treatments. Specific activity of FAS was stimulated slightly by biotin-deficiency but Hg reduced activity to control values in deficient chicks. Specific activity of ACC was reduced to one-half of control values by biotin deficiency and Hg had no further effect. Incorporation of /sup 14/C-acetate into hepatic fatty acids was reduced markedly by biotin-deficiency but Hg returned incorporation to control values in deficient chicks. ACC is presumably the rate-limiting enzyme for lipogenesis. Therefore, the data suggest that Hg somehow stimulates the in vivo activity of this enzyme in biotin-deficient chicks.
Educational Use Research
Learning Resource Type Article
Publisher Date 1977-01-01
Publisher Place United States
Journal Poult. Sci.
Volume Number 56
Issue Number 5
Organization North Carolina State Univ., Raleigh


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