|Author||Hamilton, J. C. ♦ Donaldson, W. E.|
|Source||United States Department of Energy Office of Scientific and Technical Information|
|Subject Keyword||RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT. ♦ ENZYMES ♦ BIOSYNTHESIS ♦ MERCURY ♦ BIOLOGICAL EFFECTS ♦ CARBON 14 ♦ CHICKENS ♦ METABOLIC ACTIVATION ♦ METABOLISM ♦ STIMULATION ♦ ANIMALS ♦ BETA DECAY RADIOISOTOPES ♦ BETA-MINUS DECAY RADIOISOTOPES ♦ BIRDS ♦ CARBON ISOTOPES ♦ ELEMENTS ♦ EVEN-EVEN NUCLEI ♦ FOWL ♦ ISOTOPES ♦ LIGHT NUCLEI ♦ METALS ♦ NUCLEI ♦ RADIOISOTOPES ♦ SYNTHESIS ♦ VERTEBRATES ♦ YEARS LIVING RADIOISOTOPES 560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)|
|Abstract||Broilers were fed control or biotin-deficient diets based upon glucose and casein starting at day-old. At 7 days, one-half the chicks fed the biotin-deficient diet were administered 200 ppm Hg (as HgCl/sub 2/) continuously in the drinking water, while the remaining biotin-deficient chicks and the control chicks continued to receive tap water. At 4 weeks, hepatic fatty acid synthetse (FAS) and acetyl-CoA carboxylase (ACC) activities and in vivo lipogenesis from /sup 14/C-acetate were measured in randomly selected chicks from each of the 3 treatments. Specific activity of FAS was stimulated slightly by biotin-deficiency but Hg reduced activity to control values in deficient chicks. Specific activity of ACC was reduced to one-half of control values by biotin deficiency and Hg had no further effect. Incorporation of /sup 14/C-acetate into hepatic fatty acids was reduced markedly by biotin-deficiency but Hg returned incorporation to control values in deficient chicks. ACC is presumably the rate-limiting enzyme for lipogenesis. Therefore, the data suggest that Hg somehow stimulates the in vivo activity of this enzyme in biotin-deficient chicks.|
|Learning Resource Type||Article|
|Publisher Place||United States|
|Organization||North Carolina State Univ., Raleigh|
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