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Author Carboni, Paulo ♦ Bernert, Bruna Ferreira ♦ Roman, Alex ♦ Torres, Luiz Fernando Bleggi
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher Sociedade Brasileira de Patologia Clínica
File Format HTM / HTML
Date Created 2015-12-15
Copyright Year ©2013
Language English
Subject Domain (in LCC) RB1-214
Subject Keyword Neoplasias encefálicas congênitas ♦ Meduloblastoma ♦ Pathology ♦ Diferenciação celular ♦ Medicine ♦ Imuno-histoquímica
Abstract We report the case of a 2 month-old patient with a large, probably congenital, posterior fossa tumor. Hematoxylin and eosin staining (HE), reticulin and immunohistochemistry revealed a medulloblastoma with extensive nodularity, showing ganglioglial differentiation, high proliferative index in the primitive neuroectodermal tumor (PNET) area and low proliferative index in the ganglioglial maturation area. Ganglioglial differentiation is a rare event in medulloblastomas and its mechanism is still unknown. Previous surgery, radiation and chemotherapy may contribute to differentiation in astrocytic and nerve cells. In this case, however, the differentiation was already present in the first specimen, prior to any surgical or therapeutic procedure.
ISSN 16762444
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2013-12-01
e-ISSN 16762444
Journal Jornal Brasileiro de Patologia e Medicina Laboratorial
Volume Number 49
Issue Number 6
Page Count 4
Starting Page 433
Ending Page 436

Source: Directory of Open Access Journals (DOAJ)