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Author Sohrabi, Mahmoud Reza ♦ Kamali, Naghmeh ♦ Khakpour, Mazyar
Source J-STAGE
Content type Text
Publisher The Japan Society for Analytical Chemistry
Language English
Abstract In this work, a combined discrete and continuous wavelet transform analysis was developed for simultaneous spectrophotometric determinations of metformin hydrochloride and glibenclamide, two antidiabetic drugs, in binary mixtures without any chemical pretreatment. Absorption spectra were subjected to the 4-level db4 discrete wavelet transform (DWT) for signal de-noising. Selected continuous wavelet transform (CWT) families (rbio3.1 with scaling factor, a = 80, and gaus2, a = 60) were applied on these de-noised signals. Finally, a zero-crossing technique was used for the construction of calibration curves for both drugs. The proposed method was validated by analyzing synthetic mixtures of the investigated drugs with various concentrations. The amount of metformin hydrochloride and glibenclamide were determined by using CWT amplitudes in zero-crossing points. The mean recovery values of metformin hydrochloride and glibenclamide were found between 98.6 – 102.0 and 97.9 – 102.4% for rbio3 and 98.3 – 101.2 and 97.1 – 101.4% for gaus2 families, respectively. The obtained results showed that the developed method is a simple, rapid and precise procedure for the simultaneous determination of metformin hydrochloride and glibenclamide in binary mixtures.
ISSN 09106340
Learning Resource Type Article
Publisher Date 2011-10-10
e-ISSN 13482246
Journal Analytical Sciences(analsci)
Volume Number 27
Issue Number 10
Page Count 1
Starting Page 1037
Ending Page 1037


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