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Author Wang, Huai You ♦ Xiao, Yan ♦ Han, Juan
Source J-STAGE
Content type Text
Publisher The Japan Society for Analytical Chemistry
Language English
Abstract A sensitive and selective method for the simultaneous determination of carvedilol and ampicillin sodium (AS) in the presence of human serum albumin (HSA) is described. The maximum emission wavelengths of carvedilol and AS are at 357 nm and 426 nm with excitation at 254 nm, respectively. The first-derivative peaks of carvedilol and AS were at 337 nm and 398 nm, respectively. The linear-regression equations of the calibration graphs of carvedilol and AS were C = 0.0001H - 0.0063 and C = 1.530H - 43.84; the correlation coefficients were 0.9990 and 0.9986, respectively. The detection limits were 1 ng $ml^{-1}$ for carvedilol and 23 µg $ml^{-1}$ for AS, respectively. The effects of the pH, the stability of carvedilol and AS and foreign ions on the determination of carvedilol and AS were examined. The recoveries of carvedilol and AS were measured. This method is simple and can be used for the determination of carvedilol and AS in human serum and urine samples with satisfactory results.
ISSN 09106340
Learning Resource Type Article
Publisher Date 2005-01-01
e-ISSN 13482246
Journal Analytical Sciences(analsci)
Volume Number 21
Issue Number 5
Page Count 4
Starting Page 537
Ending Page 540


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