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Author Nakao, Ryuji ♦ Furutsuka, Kenji ♦ Yamaguchi, Masatoshi ♦ Suzuki, Kazutoshi
Source J-STAGE
Content type Text
Publisher The Japan Society for Analytical Chemistry
Language English
Abstract A sensitive, selective and rapid high-performance liquid chromatographic (HPLC) method with chemiluminescence (CL) detection was developed and validated for the analysis of positron emission tomography (PET) radiopharmaceuticals. This method is based on the CL reaction of PET compounds with tris(2,2′-bipyridyl)ruthenium(II) $[Ru(bpy)_{3}^{2+}]$ and acidic potassium permanganate $[KMnO_{4}].$ After optimization of the reaction conditions, 12 of the 14 PET compounds investigated could be successfully detected and showed good performance in terms of sensitivity, linearity and reproducibility. In particular, for compounds with a tertiary amine functional group, the limits of detection were ppb levels for a 20 µL injection volume. Finally, this method was used to determine PET compounds for calculating of specific radioactivity in pharmaceutical samples.
ISSN 09106340
Learning Resource Type Article
Publisher Date 2007-01-01
e-ISSN 13482246
Journal Analytical Sciences(analsci)
Volume Number 23
Issue Number 2
Page Count 5
Starting Page 151
Ending Page 155


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