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Author Sato, Takeshi ♦ Tanaka, Toshihiro ♦ Nishiofuku, Hideyuki ♦ Fukuoka, Yasushi ♦ Sakaguchi, Hiroshi ♦ Masada, Tetsuya ♦ Tatsumoto, Shota ♦ Marugami, Nagaaki ♦ Takano, Masato ♦ Yamato, Ichiro ♦ Sho, Masayuki ♦ Ohbayashi, Chiho ♦ Hirai, Toshiko ♦ Kichikawa, Kimihiko
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIOLOGY AND NUCLEAR MEDICINE ♦ APOPTOSIS ♦ DRUGS ♦ INFUSION ♦ LIVER ♦ MICROSPHERES ♦ NEOPLASMS ♦ PLATINUM ♦ STARCH ♦ TUMOR CELLS
Abstract PurposeThe purpose of this study is to evaluate the pharmacokinetics and histopathological findings of transarterial chemoembolization (TACE) using cisplatin powder mixed with degradable starch microspheres (DSM) (Cis/DSM-TACE) compared with cisplatin arterial infusion (Cis-AI).Materials and MethodsEighteen rabbits with VX2 liver tumors were divided into two groups: Cis/DSM-TACE (n = 9) and Cis-AI (n = 9) groups. In the Cis/DSM-TACE group, a mixture of cisplatin powder and DSM was injected until stasis of hepatic arterial flow was achieved. In the Cis-AI group, cisplatin solution was infused.ResultsThe platinum concentrations in VX2 tumors in the Cis/DSM-TACE group at 24 and 72 h were significantly elevated compared with those in the Cis-AI group (P = .016 and .019, respectively). There were no significant differences in the platinum concentrations in plasma. Histopathological examination revealed the presence of several microspheres inside the tumors at 1 h, which completely disappeared at 24 h. Tumor cell apoptosis at 1 h in the Cis/DSM-TACE group was more frequently observed compared with that in the Cis-AI group (P = .006).ConclusionsTACE using cisplatin powder mixed with DSM provides a higher drug concentration in tumors, thereby achieving stronger antitumor effects compared with arterial infusion of cisplatin solution.
ISSN 01741551
Educational Use Research
Learning Resource Type Article
Publisher Date 2017-03-15
Publisher Place United States
Journal Cardiovascular and Interventional Radiology
Volume Number 40
Issue Number 3


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