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Author Fu, Xiangdong ♦ Richards, Donald E. ♦ Ait-Ali, Tahar ♦ Hynes, Llewelyn W. ♦ Ougham, Helen ♦ Peng, Jinrong ♦ Harberd, Nicholas P.
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher American Society of Plant Biologists
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Genetics and evolution ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Pharmacology and therapeutics
Subject Domain (in MeSH) Plant Structures ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Inorganic Chemicals ♦ Organic Chemicals ♦ Macromolecular Substances ♦ Enzymes and Coenzymes ♦ Amino Acids, Peptides, and Proteins ♦ Chemical Actions and Uses ♦ Chemicals and Drugs ♦ Chemical Phenomena ♦ Genetic Phenomena ♦ Biological Sciences
Subject Keyword Discipline Botany ♦ Cysteine Endopeptidases ♦ Metabolism ♦ Gibberellins ♦ Pharmacology ♦ Hordeum ♦ Genetics ♦ Multienzyme Complexes ♦ Plant Proteins ♦ Alleles ♦ Aprotinin ♦ Enzyme Induction ♦ Drug Effects ♦ Enzyme Inhibitors ♦ Growth & Development ♦ Mutation ♦ Okadaic Acid ♦ Phenylmethylsulfonyl Fluoride ♦ Plant Leaves ♦ Proteasome Endopeptidase Complex ♦ Seeds ♦ Signal Transduction ♦ Sulfones ♦ Vanadates ♦ Alpha-amylases ♦ Biosynthesis ♦ Journal Article ♦ Research Support, Non-u.s. Gov't
Abstract DELLA proteins are nuclear repressors of plant gibberellin (GA) responses. Here, we investigate the properties of SLN1, a DELLA protein from barley that is destabilized by GA treatment. Using specific inhibitors of proteasome function, we show that proteasome-mediated protein degradation is necessary for GA-mediated destabilization of SLN1. We also show that GA responses, such as the aleurone alpha-amylase response and seedling leaf extension growth, require proteasome-dependent GA-mediated SLN1 destabilization. In further experiments with protein kinase and protein phosphatase inhibitors, we identify two additional signaling steps that are necessary for GA response and for GA-mediated destabilization of SLN1. Thus, GA signaling involves protein phosphorylation and dephosphorylation steps and promotes the derepression of GA responses via proteasome-dependent destabilization of DELLA repressors.
Description Country affiliation: United kingdom
Author Affiliation: Fu X ( John Innes Centre, Colney Lane, Norwich NR4 7UJ, United Kingdom.)
ISSN 10404651
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2002-12-01
Publisher Place United States
e-ISSN 1531298X
Volume Number 14
Issue Number 12

Source: WHO-Global Index Medicus