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Author Phreaner, C. G. ♦ Williams, M. A. ♦ Mulligan, R. M.
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher American Society of Plant Biologists
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Computer science, information & general works ♦ Library & information sciences ♦ Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Genetics and evolution ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Cells ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Amino Acids, Peptides, and Proteins ♦ Nucleic Acids, Nucleotides, and Nucleosides ♦ Biological Factors ♦ Chemicals and Drugs ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Chemical Phenomena ♦ Genetic Phenomena ♦ Immune System Phenomena ♦ Biological Sciences ♦ Information Science ♦ Information Science
Subject Keyword Discipline Botany ♦ Mitochondria ♦ Metabolism ♦ Polymorphism, Genetic ♦ Rna Editing ♦ Ribosomal Proteins ♦ Genetics ♦ Zea Mays ♦ Amino Acid Sequence ♦ Antibody Specificity ♦ Base Sequence ♦ Epitopes ♦ Molecular Sequence Data ♦ Protein Biosynthesis ♦ Rna ♦ Rna, Messenger ♦ Rna, Plant ♦ Recombinant Fusion Proteins ♦ Immunology ♦ Sequence Analysis, Dna ♦ Journal Article ♦ Research Support, U.s. Gov't, Non-p.h.s.
Abstract C-to-U editing causes specific nucleotide changes in plant mitochondrial nRNAs that are required for the restoration of the evolutionarily conserved amino acid sequence. Transcripts for the ribosomal protein S12 gene (rps12) have six C-to-U editing sites and are highly heterogeneous as a result of incomplete editing. immunological analysis demonstrated that unedited or partially edited transcripts as well as edited mRNAs are translated. The edited rps12 translation products accumulate as ribosomal subunits, but the unedited rps12 translation products are present as unassembled subunits and are not detected in the ribosomes. Thus, gene expression is polymorphic as a result of incomplete C-to-U editing, and aberrant polypeptides are present from the translation of these mRNAs. However, because only the edited translation products accumulate in mitochondrial ribosomes, the overall expression of rps12 is rendered coherent by the selection
Description Country affiliation: United States
Author Affiliation: Phreaner CG ( Department of Developmental and Cell Biology, University of California-Irvine 92717, USA.)
ISSN 10404651
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 1996-01-01
Publisher Place United States
e-ISSN 1531298X
Volume Number 8
Issue Number 1

Source: WHO-Global Index Medicus