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Author Beynon, Christopher ♦ Potzy, Anna ♦ Unterberg, Andreas W. ♦ Sakowitz, Oliver W.
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Elsevier
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Pharmacology and therapeutics ♦ Diseases ♦ Surgery & related medical specialties ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Eukaryota ♦ Organisms ♦ Nervous System Diseases ♦ Diseases ♦ Heterocyclic Compounds ♦ Chemical Actions and Uses ♦ Chemicals and Drugs ♦ Diagnosis ♦ Surgical Procedures, Operative ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Persons ♦ Persons
Subject Keyword Discipline Emergency ♦ Discipline Medicine ♦ Anticoagulants ♦ Adverse Effects ♦ Hematoma, Subdural ♦ Chemically Induced ♦ Surgery ♦ Intracranial Hemorrhages ♦ Neurosurgical Procedures ♦ Pyrazoles ♦ Pyridones ♦ Aged ♦ Female ♦ Humans ♦ Male ♦ Tomography, X-ray Computed ♦ Case Reports ♦ Journal Article
Abstract A debate has emerged regarding the safety profile of direct anticoagulants, which are increasingly prescribed for the prevention of thromboembolic events. Despite favorable safety data derived from controlled clinical trials, the absence of specific antidotes for the management of hemorrhagic complications represents a major challenge for emergency physicians. Here, we present the first report on patients treated with the direct factor Xa inhibitor apixaban and conditions requiring urgent neurosurgical intervention (intracerebral hemorrhage, n = 1; subdural hematoma, n = 1). Prothrombin complex concentrates were administered before surgery, and both patients had a favorable postsurgical course without bleeding or thromboembolic complications. Further studies are needed, but this approach seems to be suitable for the emergency management of apixaban-associated intracranial hemorrhage.
Description Author Affiliation: Beynon C ( Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany. Electronic address:; Potzy A ( Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.); Unterberg AW ( Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.); Sakowitz OW ( Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.)
ISSN 07356757
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article ♦ Case study
Publisher Date 2015-06-01
Publisher Place United States
e-ISSN 15328171
Journal The American Journal of Emergency Medicine
Volume Number 33
Issue Number 6

Source: WHO-Global Index Medicus