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Author Maruyama, Y.
Sponsorship USDOE
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword BIOLOGY AND MEDICINE ♦ ANIMAL CELLS ♦ BIOCHEMISTRY ♦ BONE MARROW ♦ DNA ♦ LETHAL DOSE ♦ MICE ♦ NUCLEIC ACIDS ♦ ORGANIC NITROGEN COMPOUNDS ♦ THYMIDINE ♦ TRACER TECHNIQUES ♦ TRITIUM ♦ TUMORS ♦ X RADIATION
Abstract Following large doses of x radiation, death of a murine ascites lymphoma cell occurred by a rapid intermitotic mechanism. The desoxyribonucleic acid (DNA) of these cells was labeled with tritiated thymidine, the cells killed by x- irradiation, and injected intravenously into recipient mice with growing ascites tumors. Tritium appeared in the DNA of the tumor and bone marrow cells of the recipient mice, with all the radioactivity present as thymine. This indicated a salvage and conservation mechanism for these molecules. (M.C.G.)
Educational Use Research
Learning Resource Type Article
Publisher Date 1964-01-01
Publisher Department Stanford Univ., Palo Alto, Calif.
Journal Nature
Volume Number 201
Organization Stanford Univ., Palo Alto, Calif.


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