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Author B, Suchand ♦ J, Krishna ♦ K, Mritunjoy ♦ Satyanarayana, G.
Source IIT Hyderabad
Content type Text
Publisher Royal Society Of Chemistry
File Format PDF
Language English
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences
Subject Keyword Chemistry
Abstract An intramolecular [Cu]-catalyzed CO bond formation for the synthesis of neoflavans is presented. Lewis acid promoted Friedel Crafts Michael addition of electron rich aromatic systems onto the double bond of the cinnamate esterwas employed to furnish a b-diaryl ester. Electrophilic aromatic bromination of the b-diaryl ester and reduction/Grignard addition furnished the required precursor alcohols. The method is applicable to the synthesis of neoflavans containing tertiary as well as quaternary carbon centers. Significantly, the neoflavan substructures are present in biologically active compounds.
ISSN 20462069
Educational Use Research
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-01-01
Page Count 5
Starting Page 13941
Ending Page 13945