Thumbnail
Access Restriction
Open

Author Cirillo, P. ♦ Hickey, E. ♦ Moss, N. ♦ Breitfelder, S. ♦ Betageri, R. ♦ Fadra, T. ♦ Gaenzler, F. ♦ Gilmore, T. ♦ Xiong, Z.
Sponsorship DOE - OFFICE OF SCIENCE
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword BASIC BIOLOGICAL SCIENCES ♦ GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE ♦ IN VITRO ♦ LIPOPOLYSACCHARIDES ♦ PHOSPHOTRANSFERASES ♦ PRODUCTION ♦ SULFONAMIDES ♦ SYNTHESIS ♦ national synchrotron light source
Abstract An effort aimed at exploring structural diversity in the N-pyrazole-N{prime}-naphthylurea class of p38 kinase inhibitors led to the synthesis and characterization of N-phenyl-N{prime}-naphthylureas. Examples of these compounds displayed excellent inhibition of TNF-{alpha} production in vitro, as well as efficacy in a mouse model of lipopolysaccharide induced endotoxemia. In addition, perspective is provided on the role of a sulfonamide functionality in defining inhibitor potency.
ISSN 0960894X
Educational Use Research
Learning Resource Type Article
Publisher Date 2009-01-01
Publisher Place United States
Journal Bioorganic and Medicinal Chemistry Letters
Volume Number 19
Issue Number 9
Technical Publication No. BNL-95744-2011-JA
Organization Brookhaven National Laboratory (BNL) National Synchrotron Light Source


Open content in new tab

   Open content in new tab