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Author Manguro, Lawrence Onyango A. ♦ Lemmen, Peter ♦ Hao, Pang ♦ Wong, Keng-Chong
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Taylor & Francis
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Microorganisms, fungi & algae ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Plant Structures ♦ Anatomy ♦ Eukaryota ♦ Bacteria ♦ Organisms ♦ Organic Chemicals ♦ Carbohydrates ♦ Chemicals and Drugs ♦ Diagnosis ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Chemical Phenomena ♦ Biological Sciences ♦ Geographic Locations ♦ Geographic Locations
Subject Keyword Discipline Chemistry ♦ Discipline Pharmacology ♦ Myrsinaceae ♦ Chemistry ♦ Saponins ♦ Isolation & Purification ♦ Triterpenes ♦ Enterococcus Faecalis ♦ Drug Effects ♦ Escherichia Coli ♦ Kenya ♦ Microbial Sensitivity Tests ♦ Molecular Structure ♦ Nuclear Magnetic Resonance, Biomolecular ♦ Salmonella Typhi ♦ Pharmacology ♦ Staphylococcus Aureus ♦ Streptococcus Pneumoniae ♦ Vibrio Cholerae ♦ Wood ♦ Journal Article ♦ Research Support, Non-u.s. Gov't
Abstract Phytochemical analysis of aqueous MeOH extract of Maesa lanceolata stem wood has led to the isolation of four new triterpene saponins characterized as 16 ,21ß-diacetoxy-22 -angeloyl-28-hydroxyolean-12-ene 3-O-[ -rhamnopyranosyl-(1⠳⠳ â 6â ´)-ß-glucopyranosyl-(1â ´ â 3')][ß-glucopyranosyl-(1â ³ â 2')]-ß-glucuronopyranoside (1), 16 -acetoxy-21ß-hydroxy-22 -angeloyl-13ß,28-oxydoolean-28 -ol 3-O-[ -rhamnopyranosyl-(1⠳⠳ â 6â ´)-ß-glucopyranosyl-(1â ´ â 4')][ß-glucopyranosyl-(1â ³ â 2')]- -arabinopyranoside (2), 16 -acetoxy-21ß,22 -diangeloyl-13ß,28-epoxyoleanane 3-O-[ -rhamnopyranosyl-(1⠳⠳ â 6â ´)-ß-glucopyranosyl-(1â ´ â 4')][ß-glucopyranosyl-(1â ³ â 2')]-ß-xylopyranoside (3), and 16 ,22 -diacetoxy-13ß,28-oxydoolean-28 -ol 3-O-[ß-glucopyranosyl-(1â ³ â 2')][ß-glucopyranosyl-(1â ´ â 3')]-ß-glucuronopyranoside (4), together with the known compounds ß-acetylamyrin, physcion, emodin, chrysophanol, ursolic acid, 16 -hydroxy-12-oleanene 3-O-glucoside, ß-amyrin, sitosterol 3-O-ß-glucoside, stigmasterol, and 3ß,28-dihydroxyolean-12-ene. Their structural elucidation was accomplished by homo- and heteronuclear 2D NMR technique as well as comparison with data from known compounds. The in vitro antibacterial activity of the aqueous MeOH extract was also investigated and zones of inhibition ranging from 32 ± 1.1 to 14 ± 0.2 mm were observed. Among the isolates, compound 1 was the most active with an minimum inhibitory concentration value of 25 µg/ml against Staphylococcus aureus.
Spatial Coverage Kenya
Description Country affiliation: Kenya
Author Affiliation: Manguro LO ( Chemistry Department, Maseno University, PO Box 333-40105, Maseno, Kenya. kamanguro@yahoo.com)
ISSN 10286020
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2012-01-01
Publisher Place Great Britain (UK)
e-ISSN 14772213
Journal Journal of Asian Natural Products Research
Volume Number 14
Issue Number 11


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Source: WHO-Global Index Medicus