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Author Deng, Hui-Dong ♦ Mei, Wen-Li ♦ Wang, Hui ♦ Guo, Zhi-Kai ♦ Dong, Wen-Hua ♦ Wang, Hao ♦ Li, Shao-Peng ♦ Dai, Hao-Fu
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Taylor & Francis
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Microorganisms, fungi & algae ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Plant Structures ♦ Anatomy ♦ Eukaryota ♦ Bacteria ♦ Organisms ♦ Heterocyclic Compounds ♦ Complex Mixtures ♦ Chemical Actions and Uses ♦ Chemicals and Drugs ♦ Diagnosis ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Chemical Phenomena ♦ Biological Sciences
Subject Keyword Discipline Chemistry ♦ Discipline Pharmacology ♦ Alkaloids ♦ Isolation & Purification ♦ Carbazoles ♦ Clausena ♦ Chemistry ♦ Drugs, Chinese Herbal ♦ Glycoside Hydrolase Inhibitors ♦ Staphylococcus Aureus ♦ Drug Effects ♦ Pharmacology ♦ Anti-bacterial Agents ♦ Inhibitory Concentration 50 ♦ Microbial Sensitivity Tests ♦ Molecular Structure ♦ Nuclear Magnetic Resonance, Biomolecular ♦ Plant Stems ♦ Journal Article ♦ Research Support, Non-u.s. Gov't
Abstract A new carbazole alkaloid, claulansine K (1), together with six known carbazole alkaloids (2-7), was isolated from the peels of Clausena lansium (Lour.) Skeels. The new compound was elucidated using a combination of 1D and 2D NMR (HMQC, HMBC, COSY, and ROESY) techniques, and HR-EI-MS analyses. Compound 1 showed in vitro -glucosidase inhibitory activity with the IC50 value of 0.11 mM. Compound 2 exhibited moderate antibacterial activity against Staphylococcus aureus with the diameter of inhibition zone of 14.2 mm.
Description Country affiliation: China
Author Affiliation: Deng HD ( a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.)
ISSN 10286020
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-10-01
Publisher Place Great Britain (UK)
e-ISSN 14772213
Journal Journal of Asian Natural Products Research
Volume Number 16
Issue Number 10


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Source: WHO-Global Index Medicus