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Author Thao, Do Thi ♦ Phuong, Do Thi ♦ Hanh, Tran Thi Hong ♦ Thao, Nguyen Phuong ♦ Cuong, Nguyen Xuan ♦ Nam, Nguyen Hoai ♦ Minh, Chau Van
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Taylor & Francis
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Cells ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Organic Chemicals ♦ Chemical Actions and Uses ♦ Chemicals and Drugs ♦ Diagnosis ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Chemical Phenomena ♦ Biological Sciences ♦ Geographic Locations ♦ Geographic Locations
Subject Keyword Discipline Chemistry ♦ Discipline Pharmacology ♦ Diterpenes, Clerodane ♦ Isolation & Purification ♦ Scutellaria ♦ Chemistry ♦ Antineoplastic Agents, Phytogenic ♦ Pharmacology ♦ Diterpenes ♦ Drug Screening Assays, Antitumor ♦ Female ♦ Hl-60 Cells ♦ Hep G2 Cells ♦ Humans ♦ Molecular Structure ♦ Nuclear Magnetic Resonance, Biomolecular ♦ Vietnam ♦ Journal Article ♦ Research Support, Non-u.s. Gov't
Abstract Various chromatographic separations of the aerial parts of Scutellaria barbata afforded two new neoclerodane diterpenoids, scutebatas S and T (1 and 2), along with scutebata D (3). Their structures were elucidated by spectroscopic methods including high-resolution electrospray ionization mass spectrometry, 1D and 2D NMR and comparison with the literature values. Compounds 1 and 3 exhibited moderate cytotoxic activities against HL-60 (promyeloblast) human cancer cells. Weak cytotoxic effects toward four tested human cancer cell lines including KB (epidermoid carcinoma), LU-1 (lung adenocarcinoma), MCF7 (breast cancer), and Hep-G2 (hepatoma cancer) were observed for 1 and 3; whereas 2 was inactive on all five tested cell lines.
Spatial Coverage Vietnam
Description Author Affiliation: Thao do T ( a Institute of Biotechnology (IBT), Vietnam Academy of Science and Technology (VAST) , 18 Hoang Quoc Viet road, Caugiay , Hanoi , Viet Nam.)
ISSN 10286020
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2014-01-01
Publisher Place Great Britain (UK)
e-ISSN 14772213
Journal Journal of Asian Natural Products Research
Volume Number 16
Issue Number 4


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Source: WHO-Global Index Medicus