Thumbnail
Access Restriction
Subscribed

Author Xiao, Chao-Jiang ♦ Zhang, Yu ♦ Qiu, Lin ♦ Xu, Wei ♦ Zhao, Ming-Zao ♦ Dong, Xiang ♦ Jiang, Bei
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Taylor & Francis
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Pharmacology and therapeutics
Subject Domain (in MeSH) Plant Structures ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Organic Chemicals ♦ Complex Mixtures ♦ Chemical Actions and Uses ♦ Chemicals and Drugs ♦ Chemical Phenomena ♦ Biological Sciences
Subject Keyword Discipline Chemistry ♦ Discipline Pharmacology ♦ Antioxidants ♦ Isolation & Purification ♦ Pharmacology ♦ Drugs, Chinese Herbal ♦ Phenylpropionates ♦ Schistosomicides ♦ Animals ♦ Chemistry ♦ Biphenyl Compounds ♦ Free Radical Scavengers ♦ Molecular Structure ♦ Picrates ♦ Plant Roots ♦ Schistosoma ♦ Drug Effects ♦ Journal Article ♦ Research Support, Non-u.s. Gov't
Abstract A new phenylpropanoid, (E)-2,3,4-trimethoxy-5-(1-propenyl)phenol (1), along with five known aromatic compounds (2-6), was isolated from the methanol extract of roots of Astragalus englerianus. Their structures were elucidated based on the analyses of extensive spectroscopic data and comparison of their physicochemical properties. Compounds 1 and 2 were evaluated schistosomicidal activities, and all the isolated compounds were tested for their antioxidant activities in vitro. Compound 1 showed significant schistosomicidal activity with worm mortality rates of 66.7% and 83.3% within 12 and 24 h in a drug-containing (1.16 mM) RPMI 1640 medium, respectively. Also, compound 1 exhibited excellent antioxidant activity (2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl free radical-scavenging capability) with an IC50 value of 81.3 ± 1.3 µM.
Description Country affiliation: China
Author Affiliation: Xiao CJ ( a College of Pharmacy and Chemistry, Institute of Materia Medica, Dali University , Dali 671000 , China.)
ISSN 10286020
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2015-01-01
Publisher Place Great Britain (UK)
e-ISSN 14772213
Journal Journal of Asian Natural Products Research
Volume Number 17
Issue Number 7


Source: WHO-Global Index Medicus