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Author Smutna, Miriam ♦ Svoboda, Martin ♦ Breinekova, Klara
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Multidisciplinary Digital Publishing Institute
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human physiology ♦ Pharmacology and therapeutics
Subject Domain (in MeSH) Eukaryota ♦ Organisms ♦ Inorganic Chemicals ♦ Heterocyclic Compounds ♦ Polycyclic Compounds ♦ Chemicals and Drugs ♦ Physiological Phenomena ♦ Immune System Phenomena ♦ Biological Sciences
Subject Keyword Discipline Biotechnology ♦ Hydrocortisone ♦ Blood ♦ Immunity, Innate ♦ Drug Effects ♦ Immunology ♦ Iron ♦ Pharmacology ♦ Pterins ♦ Stress, Physiological ♦ Animals ♦ Biological Markers ♦ Swine ♦ Journal Article ♦ Research Support, Non-u.s. Gov't
Abstract The aim of the presented study was to assess the effect of a single administration of Fe(3+)-dextran on immune cell counts and pterin biomolecule production as novel sensors of the piglets' immune system activation, and to determine concentrations of cortisol, a traditional hormonal biosensor of the stress response. Pterins (neopterin and biopterin) in the piglets' blood serum were analyzed by separation using reversed-phase HPLC. A single dose of Fe(3+)-dextran produced a special stress situation in the piglets' organism which manifested itself by an increased production of neopterin (p < 0.05) and biopterin (p < 0.01) in the experimental piglets. Changes in cortisol concentrations and leukocyte counts were influenced by handling stress and were not specifically correlated to iron dextran application. Iron concentrations in the internal environment of the experimental piglets' group were higher by an order of magnitude compared with the controls, and the highest serum concentrations of iron (p < 0.01) were reached 24 h following Fe(3+)-dextran administration. The data presented offer a new perspective on the evaluation of stress situations in the animal organism and, not least importantly, extends the rather modest current list of references on the role of pterins in livestock animals.
Description Country affiliation: Czech Republic
Author Affiliation: Smutna M ( Department of Biochemistry, Chemistry and Biophysics, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1/3, Brno, 612 42, Czech Republic. smutnam@vfu.cz)
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2010-01-01
Publisher Place Switzerland
e-ISSN 14248220
Journal Sensors
Volume Number 10
Issue Number 1


Source: WHO-Global Index Medicus