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Author Chen, Chang-Sheng ♦ Xu, Xiao-Ding ♦ Wang, Ya ♦ Yang, Juan ♦ Jia, Hui-Zhen ♦ Cheng, Han ♦ Chu, Chih-Chang ♦ Zhuo, Ren-Xi ♦ Zhang, Xian-Zheng
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Wiley-VCH
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Computer science, information & general works ♦ Library & information sciences ♦ Philosophy & psychology ♦ Psychology ♦ Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Incidence & prevention of disease ♦ Pharmacology and therapeutics ♦ Diseases ♦ Agriculture & related technologies
Subject Domain (in MeSH) Cells ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Neoplasms ♦ Diseases ♦ Amino Acids, Peptides, and Proteins ♦ Chemicals and Drugs ♦ Psychological Phenomena and Processes ♦ Psychiatry and Psychology ♦ Physical Phenomena ♦ Chemical Phenomena ♦ Biological Sciences ♦ Technology, Industry, and Agriculture ♦ Technology and Food and Beverages ♦ Information Science ♦ Information Science
Subject Keyword Discipline Nanotechnology ♦ Carcinoma, Hepatocellular ♦ Diagnosis ♦ Liver Neoplasms ♦ Nanofibers ♦ Peptides ♦ Chemistry ♦ Amino Acid Sequence ♦ Animals ♦ Cos Cells ♦ Cercopithecus Aethiops ♦ Color ♦ Hep G2 Cells ♦ Humans ♦ Molecular Sequence Data ♦ Vision, Ocular ♦ Journal Article ♦ Research Support, Non-u.s. Gov't
Abstract A unique peptide nanofibrous indicator (NFI) is fabricated by mixing a borono-peptide with alizarin red S, followed by subsequent binding and self-assembly. The NFI thus obtained exhibits an intense response to sialyl Lewis X tetrasaccharide, which is overexpressed in human hepatocellular carcinoma cell lines. Importantly, this NFI has the capability of specifically recognizing human hepatocellular liver carcinoma (HepG2) cells through the eye-detectable color change resulting from strong binding-induced displacement. This novel technique for cancer cell identification through direct unaided eye judgment will open up an innovative platform for cancer cell detection.
Description Author Affiliation: Chen CS ( Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, PR China.)
ISSN 16136810
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2013-03-25
Publisher Place Germany
e-ISSN 16136829
Journal Small
Volume Number 9
Issue Number 6

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Source: WHO-Global Index Medicus