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Author Xiong, Lin ♦ Du, Xin ♦ Kleitz, Freddy ♦ Qiao, Shi Zhang
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Wiley-VCH
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Physiology & related subjects ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Human anatomy, cytology, histology ♦ Human physiology ♦ Pharmacology and therapeutics ♦ Diseases ♦ Agriculture & related technologies ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Cells ♦ Anatomy ♦ Eukaryota ♦ Organisms ♦ Neoplasms ♦ Diseases ♦ Inorganic Chemicals ♦ Organic Chemicals ♦ Chemical Actions and Uses ♦ Chemicals and Drugs ♦ Diagnosis ♦ Therapeutics ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Physical Phenomena ♦ Chemical Phenomena ♦ Cell Physiological Phenomena ♦ Biological Sciences ♦ Technology, Industry, and Agriculture ♦ Technology and Food and Beverages
Subject Keyword Discipline Nanotechnology ♦ Cell Nucleus ♦ Metabolism ♦ Drug Delivery Systems ♦ Methods ♦ Nanoparticles ♦ Chemistry ♦ Neoplasms ♦ Pathology ♦ Silicon Dioxide ♦ Drug Effects ♦ Cell Survival ♦ Doxorubicin ♦ Pharmacology ♦ Endocytosis ♦ Flow Cytometry ♦ Hela Cells ♦ Humans ♦ Hydrodynamics ♦ Ligands ♦ Mass Spectrometry ♦ Ultrastructure ♦ Particle Size ♦ Porosity ♦ Spectrophotometry, Ultraviolet ♦ Spectroscopy, Fourier Transform Infrared ♦ Spectrum Analysis, Raman ♦ Static Electricity ♦ Thermogravimetry ♦ Journal Article ♦ Research Support, Non-u.s. Gov't
Abstract Mesoporous silica nanoparticles are modified with dual targeting ligands, i.e., folic acid and dexamethasone, to construct a cancer-cell-specific nuclear-targeted delivery system. The resulting nanocarriers can not only enhance the inhibition efficacy of doxorubicin on Hela cells through active nucleus accumulation but also reduce toxic side effects on noncancer cells though receptor-mediated selective cellular uptake.
Description Country affiliation: Australia
Author Affiliation: Xiong L ( School of Chemical Engineering, The University of Adelaide, Adelaide, SA, 5005, Australia.); Du X ( School of Chemical Engineering, The University of Adelaide, Adelaide, SA, 5005, Australia.); Kleitz F ( Department of Chemistry and Centre de Recherche sur les Matériaux Avancés (CERMA), Université Laval, Quebec City, QC, G1V 0A6, Canada.); Qiao SZ ( School of Chemical Engineering, The University of Adelaide, Adelaide, SA, 5005, Australia.)
ISSN 16136810
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2015-11-25
Publisher Place Germany
e-ISSN 16136829
Journal Small
Volume Number 11
Issue Number 44

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Source: WHO-Global Index Medicus