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Author Zhao, Chunqiu ♦ Du, Tianyu ♦ Rehman, Fawad Ur ♦ Lai, Lanmei ♦ Liu, Xiaoli ♦ Jiang, Xuerui ♦ Li, Xiaoqi ♦ Chen, Yun ♦ Zhang, Hang ♦ Sun, Yi ♦ Luo, Shouhua ♦ Jiang, Hui ♦ Selke, Matthias ♦ Wang, Xuemei
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Wiley-VCH
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Technology ♦ Medicine & health
Abstract Cancer treatment has a far greater chance of success if the neoplasm is diagnosed before the onset of metastasis to vital organs. Hence, cancer early diagnosis is extremely important and remains a major challenge in modern therapeutics. In this contribution, facile and new method for rapid multimodal tumor bioimaging is reported by using biosynthesized iron complexes and gold nanoclusters via simple introduction of AuCl and Fe ions. The observations demonstrate that the biosynthesized Au nanoclusters may act as fluorescent and computed tomography probes for cancer bioimaging while the iron complexes behave as effective contrast agent for magnetic resonance imaging. The biosynthesized iron complexes and gold nanoclusters are found biocompatible in vitro (MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay) and in vivo for all the vital organs of circulatory and excretory system. These observations raise the possibility that the biosynthesized probes may find applications in future clinical diagnosis for deep seated early neoplasms by multimodal imaging.
Description Country affiliation: China
Author Affiliation: Zhao C ( State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.); Du T ( State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.); Rehman FU ( State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.); Lai L ( State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.); Liu X ( State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.); Jiang X ( State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.); Li X ( Nanjing Foreign Language School, Nanjing, 210096, China.); Chen Y ( State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.); Zhang H ( State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.); Sun Y ( Laboratory of the Signal and Image Processing, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.); Luo S ( Laboratory of the Signal and Image Processing, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.); Jiang H ( State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.); Selke M ( Department of Chemistry and Biochemistry, California State University, Los Angeles, CA, 90032, USA.); Wang X ( State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.)
ISSN 16136810
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2016-12-01
Publisher Place Germany
e-ISSN 16136829
Journal Small
Volume Number 12
Issue Number 45


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Source: WHO-Global Index Medicus