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Author Couvreur, Patrick ♦ Reddy, L. Harivardhan ♦ Mangenot, Stéphanie ♦ Poupaert, Jacques H. ♦ Desmaële, Didier ♦ Lepêtre-Mouelhi, Sinda ♦ Pili, Barbara ♦ Bourgaux, Claudie ♦ Amenitsch, H. ♦ Ollivon, Michel
Source World Health Organization (WHO)-Global Index Medicus
Content type Text
Publisher Wiley-VCH
File Format HTM / HTML
Language English
Difficulty Level Medium
Subject Domain (in DDC) Natural sciences & mathematics ♦ Chemistry & allied sciences ♦ Life sciences; biology ♦ Biochemistry ♦ Natural history of organisms ♦ Technology ♦ Medicine & health ♦ Pharmacology and therapeutics ♦ Diseases ♦ Agriculture & related technologies ♦ Manufacture for specific uses ♦ Precision instruments & other devices
Subject Domain (in MeSH) Eukaryota ♦ Organisms ♦ Neoplasms ♦ Diseases ♦ Organic Chemicals ♦ Heterocyclic Compounds ♦ Macromolecular Substances ♦ Chemical Actions and Uses ♦ Chemicals and Drugs ♦ Diagnosis ♦ Investigative Techniques ♦ Analytical, Diagnostic and Therapeutic Techniques and Equipment ♦ Natural Science Disciplines ♦ Physical Sciences ♦ Technology, Industry, and Agriculture ♦ Technology and Food and Beverages
Subject Keyword Discipline Nanotechnology ♦ Antineoplastic Agents ♦ Chemistry ♦ Nanostructures ♦ Animals ♦ Administration & Dosage ♦ Cryoelectron Microscopy ♦ Deoxycytidine ♦ Analogs & Derivatives ♦ Leukemia P388 ♦ Drug Therapy ♦ Macromolecular Substances ♦ Mice ♦ Mice, Inbred Dba ♦ Models, Molecular ♦ Ultrastructure ♦ Nanotechnology ♦ Scattering, Small Angle ♦ Squalene ♦ X-ray Diffraction ♦ Journal Article ♦ Research Support, Non-u.s. Gov't
Abstract In this study, the dynamically folded conformation of squalene (SQ) is taken advantage of to link this natural compound to the anticancer nucleoside analogue gemcitabine (gem) in order to achieve the spontaneous formation of nanoassemblies (SQgem) in water. Cryogenic transmission electron microscopy examination reveals particles (104 nm) with a hexagonal or multifaceted shape that display an internal structure made of reticular planes, each particle being surrounded by an external shell. X-ray diffraction evidences the hexagonal molecular packing of SQgem, resulting from the stacking of direct or inverse cylinders. The respective volumes of the gem and SQ molecules as well as molecular modeling of SQgem suggest the stacking of inverse hexagonal phases, in which the central aqueous core, consisting of water and gem molecules, is surrounded by SQ moieties. These SQgem nanoassemblies also exhibit impressively greater anticancer activity than gem against a solid subcutaneously grafted tumor, following intravenous administration. To our knowledge, this is the first demonstration of hexagonal phase organization with a SQ derivative.
Description Country affiliation: France
Author Affiliation: Couvreur P ( Université Paris-Sud XI, Faculté de Pharmacie, UMR CNRS 8612, IFR 141, 92296 Châtenay-Malabry Cedex, France.)
ISSN 16136810
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Reading ♦ Research ♦ Self Learning
Interactivity Type Expositive
Education Level UG and PG
Learning Resource Type Article
Publisher Date 2008-02-01
Publisher Place Germany
e-ISSN 16136829
Journal Small
Volume Number 4
Issue Number 2


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Source: WHO-Global Index Medicus