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Author Kong, Zhe ♦ Wan, Xuechao ♦ Zhang, Yalong ♦ Zhang, Pu ♦ Zhang, Yingyi ♦ Zhang, Xiaona ♦ Qi, Xiaoxiang ♦ Wu, Hai ♦ Huang, Jianfeng ♦ Li, Yao
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword APPLIED LIFE SCIENCES ♦ ANDROGENS ♦ ANIMAL TISSUES ♦ APOPTOSIS ♦ CELL CYCLE ♦ CELL PROLIFERATION ♦ DIAGNOSIS ♦ EXONS ♦ NEOPLASMS ♦ ONCOGENES ♦ PROSTATE ♦ RNA ♦ RNA POLYMERASES
Abstract Prostate cancer (PCa) is one of the most commonly diagnosed cancers in males worldwide. Circular RNA (circRNA) is a unique class of RNA transcribed by RNA polymerase II characterized by jointing 3′ and 5′ ends together via exon or intron circularization. However, the molecular functions of circRNAs in prostate cancer have rarely been explored. In present study, we found circ-SMARCA5 was up-regulated in prostate cancer samples compared to match normal tissues. We also observed circ-SMARCA5 expression was significantly induced after DHT treatment. Functional experiments showed circ-SMARCA5 acted as an oncogene in prostate cancer by promoting cell cycle and inhibiting cell apoptosis. We thought this study provided useful information for exploring circRNAs as potential therapeutic and prognostic targets for prostate cancer. - Highlights: • To our knowledge, this is the first study to explore the molecular functions of circRNA in prostate cancer. • Our study showed that circ-SMARCA5 promoted cell proliferation and inhibited cell apoptosis in prostate cancer. • circ-SMARCA5 was for the first time reported as an androgen-responsive circRNA. • circ-SMARCA5 was for the first time reported to be up-regulated in prostate cancer.
ISSN 0006291X
Educational Use Research
Learning Resource Type Article
Publisher Date 2017-11-25
Publisher Place United States
Journal Biochemical and Biophysical Research Communications
Volume Number 493
Issue Number 3


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