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Author Cohen, L.
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword BIOLOGY AND MEDICINE ♦ BARIUM 140 ♦ BISMUTH 206 ♦ CANCER ♦ CHROMIUM 51 ♦ DECAY ♦ EFFICIENCY ♦ GAMMA RADIATION ♦ GOLD 198 ♦ IODINE 131 ♦ IRIDIUM 192 ♦ LANTHANUM ♦ MATHEMATICS ♦ MEASURED VALUES ♦ MEDICINE ♦ RADIATION DOSES ♦ RADIATION INJURIES ♦ RADIOTHERAPY ♦ RADON 222 ♦ RBE ♦ SKIN ♦ TANTALUM 182
Abstract It is shown that the optimal biological dosage factors for permanent implants of gamma-ray emitting radioactive sources can be estimated by using empirical formulae relating the observed reactions of irradiated squamous cancer and normal human skin to the physical dosage, the relative biological efficiency of the radiation used, the size of the treated field, and the timeparameter appropriate to the exponentially decaying source. On this basis the optimal initial dose-rates (r/hr) or, in the case of discrete grains, the optimal initial millicurie content per grain, for interstitial application of Au/sup 198/, Rn/sup 222/, Bi/sup 206/, I/sup 131/, Ba/sup 140/-La Cr/sup 51/, Ir/sup 192/, and Ta/sup 182/ are tabulated. The longer-lived materials are shown to have certain advantages, and it is suggested that moderately long-lived sources with half- lives of the order of 20 days are likely to prove clinically superior to conventionally used materials. (auth)
Educational Use Research
Learning Resource Type Article
Publisher Date 1958-01-01
Journal Phys. in Med. Biol.
Volume Number 2
Organization General Hospital, Johannesburg, South Africa


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