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Author Lee, Hyun Woo ♦ Noh, O. Kyu ♦ Oh, Young-Taek ♦ Choi, Jin-Hyuk ♦ Chun, Mison ♦ Kim, Hwan-Ik ♦ Heo, Jaesung ♦ Ahn, Mi Sun ♦ Park, Seong Yong ♦ Park, Rae Woong ♦ Yoon, Dukyong
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIOLOGY AND NUCLEAR MEDICINE ♦ CHEMOTHERAPY ♦ LUNGS ♦ NEOPLASMS ♦ PATIENTS ♦ RADIOTHERAPY ♦ SURGERY
Abstract Purpose: Postoperative radiation therapy (PORT) and postoperative chemotherapy (POCT) can be administered as adjuvant therapies in patients with non-small cell lung cancer (NSCLC). The aim of this study was to present the clinical outcomes in patients treated with PORT-first with or without subsequent POCT in stage IIIA-N2 NSCLC. Methods and Materials: From January 2002 to November 2014, the conditions of 105 patients with stage IIIA-N2 NSCLC who received PORT-first with or without subsequent POCT were analyzed. PORT was initiated within 4 to 6 weeks after surgical resection. Platinum-based POCT was administered 3 to 4 weeks after the completion of PORT. We analyzed the outcomes and the clinical factors affecting survival. Results: Of 105 patients, 43 (41.0%) received POCT with a median of 4 cycles (range, 2-6 cycles). The follow-up times ranged from 3 to 123 months (median, 30 months), and the 5-year overall survival (OS) was 40.2%. The 5-year OS of patients treated with PORT and POCT was significantly higher than that of patients with PORT (61.3% vs 29.2%, P<.001). The significant prognostic factors affecting OS were the use of POCT (hazard ratio [HR] = 0.453, P=.036) and type of surgery (pneumonectomy/lobectomy; HR = 2.845, P<.001). Conclusions: PORT-first strategy after surgery appeared not to compromise the clinical outcomes in the treatment of stage IIIA-N2 NSCLC. The benefit of POCT on OS was preserved even in the PORT-first setting. Further studies are warranted to compare the sequencing of PORT and POCT, guaranteeing the proper use of POCT.
ISSN 03603016
Educational Use Research
Learning Resource Type Article
Publisher Date 2016-03-01
Publisher Place United States
Journal International Journal of Radiation Oncology, Biology and Physics
Volume Number 94
Issue Number 3


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