|Author||Lewis, F. A. ♦ Leef, J. L.|
|Source||United States Department of Energy Office of Scientific and Technical Information|
|Subject Keyword||RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT. ♦ BASIC BIOLOGICAL SCIENCES ♦ APPLIED LIFE SCIENCES ♦ SCHISTOSOMA ♦ FREEZING ♦ INFECTIVITY ♦ RADIOPRESERVATION ♦ VACCINES ♦ CHEMICAL PREPARATION ♦ TESTING ♦ CESIUM 137 ♦ COBALT 60 ♦ CRYOBIOLOGY ♦ INOCULATION ♦ MICE ♦ SCHISTOSOMIASIS ♦ ALKALI METAL ISOTOPES ♦ ANIMALS ♦ BETA DECAY RADIOISOTOPES ♦ BETA-MINUS DECAY RADIOISOTOPES ♦ BIOLOGY ♦ CESIUM ISOTOPES ♦ COBALT ISOTOPES ♦ DISEASES ♦ HELMINTHS ♦ INFECTIOUS DISEASES ♦ INTERMEDIATE MASS NUCLEI ♦ INTERNAL CONVERSION RADIOISOTOPES ♦ IRRADIATION ♦ ISOMERIC TRANSITION ISOTOPES ♦ ISOTOPES ♦ MAMMALS ♦ MINUTES LIVING RADIOISOTOPES ♦ NUCLEI ♦ ODD-EVEN NUCLEI ♦ ODD-ODD NUCLEI ♦ PARASITIC DISEASES ♦ PLATYHELMINTHS ♦ PRESERVATION ♦ RADIOISOTOPES ♦ RODENTS ♦ SYNTHESIS ♦ TREMATODES ♦ VERTEBRATES ♦ YEARS LIVING RADIOISOTOPES 560134* -- Radiation Effects on Microorganisms-- Vaccine Preparation & Other Applications-- (-1987) ♦ Physiological Systems ♦ Radiation SourcesUse in Medical Supply Sterilization(-1987)|
|Abstract||Protection against a Schistosoma mansoni cercarial challenge was evaluated in mice immunized with a vaccine composed of 10-krad-irradiated, cryopreserved schistosomules. The level of resistance induced in C57B1/6 or NMRI (CV) mice increased with the number of schistosomules injected. Up to 83% reduction in challenge worm burden was achieved when 5000 schistosomules were injected per mouse. Intramuscular injection of the vaccine was superior to subcutaneous. Multiple immunizations, up to 3 at 4-week intervals, did not increase the resistance induced by a single immunization. A high level of protection developed in as little as 2 weeks and was maintained through at least 12 weeks postimmunization. The vaccine irradiated with 10 krad from either a 60-cobalt or 137-cesium source induced equivalent levels of resistance, and no differences were found in the immunogenicity of vaccines comprised of organisms irradiated as cercariae or as 1- to 3-hr-old schistosomules. These findings are basic to the development of a cryopreserved, live vaccine against schistosomiasis of humans or domestic animals.|
|Learning Resource Type||Article|
|Publisher Place||United States|
|Organization||Biomedical Research Inst., Rockville, MD|
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