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Author Wu, Rong Tsun ♦ Okabe, Takayoshi ♦ Namikoshi, Michio ♦ Okuda, Shigenobu ♦ Nishimura, Toshio ♦ Tanaka, Nobuo
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract Cadeguomycin, a new nucleoside analog antibiotic, has been purified as colorless needle crystals by recycling preparative HPLC. The antibiotic, $C_{12}H_{14}O_{7}N_{4},$ mp 231-239°C (dec.), FD-MS: m/z 326 $(M^{+});$ is a weakly acidic substance, showing UV $λ^{H_{2}O}_{max}$ (ε) 232 (19677), 272 (6881) and 298 nm (7607), and IR $ν^{KBr}_{max}$ 1650 (C=O) and 3420 (NH or OH) $cm^{-1}.$ The UV spectrum is similar to other pyrrolo[2, 3-d]pyrimidines. The structure of cadeguomycin, 2-amino-3, 4-dihydro-4-oxo-7-β-D-ribofuranosyl-7H-pyrrolo[2, 3-d]pyrimidine-5-carboxyalcicid, has been elucidated by $^{1}H$ NMR and $^{13}C$ NMR in comparison with other pyrrolo[2, 3-d]pyrimidines and their nucleosides.
ISSN 00218820
Learning Resource Type Article
Publisher Date 1982-01-01
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 35
Issue Number 3
Page Count 6
Starting Page 279
Ending Page 284


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