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Author Perrone, Ettore ♦ Nannini, Giuliano ♦ Giudici, Franco ♦ Severino, Dino ♦ Girald, Pier Nicola ♦ Meinardi, Giuseppe ♦ Ceriani, Angelo
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract The synthesis and in vitro activity of 7α-methoxy-7β-vinylenethioacetamido cephalosporins with various substituents at the 3-position are described. These cephalosporins showed good activity against β-lactamase producing Gram-negative bacteria. 7α-Methoxy-7-[(Z)-β-cyanovinylenethioacetamido]-3-[(1-methyl-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid (3) was several times more active in vitro than cefoxitin and comparable to cefmetazole.
ISSN 00218820
Learning Resource Type Article
Publisher Date 1982-01-01
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 35
Issue Number 3
Page Count 8
Starting Page 321
Ending Page 328


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