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Author Ashley, Gary W. ♦ Carney, John R.
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract The API-MS spectra of 6-deoxyerythronolide B (6-dEB) and a number of its analogs have been studied to gain information into the fragmentation patterns of 6-deoxyerythronolides under atmospheric pressure ionization conditions. The API-MS spectrum of 6-dEB shows five major families of fragments. The spectra of a series of desmethyl-6-dEBs allow assignment of these fragment families to structural subunits as well as provide information regarding the fragmentation mechanisms. The spectrum of $[9-^{18}O]-6-dEB$ is consistent with loss of the ketone oxygen during the first dehydration, and the spectra of other oxygen-modified analogs implicate the non-obligate formation of a 5, 9-hemiacetal in the initial stages of fragmentation. These results taken together are used to propose a model for the fragmentation of 6-dEB and its analogs under API conditions.
ISSN 00218820
Learning Resource Type Article
Publisher Date 2004-09-25
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 57
Issue Number 9
Page Count 11
Starting Page 579
Ending Page 589


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