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Author Perlman, D. ♦ Capek, A.
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract Induced enzymes in Actinoplanes missouriensis convert actinomycins to the monolactone and to actinomycinic acid. These enzymes are induced by adding actinomycin, actinomycin monolactone, and peptide derivatives of 4-methyl-3-hydroxyanthranilic acid to washed cell systems. Among the compounds which do not induce these enzymes are the peptide portion of actinomycin, actinomycinic acid, and the heterodetic peptide antibiotics etamycin, vernamycin B, and albomycin. The biosynthesis of the actinomycin degrading enzymes induced by addition of actinomycin was inhibited by simultaneous addition to the washed cells of chloramphenicol, tetracycline, neomycin, streptomycin, KCN, or $Ag_{2}SO_{4}.$
ISSN 00218820
Learning Resource Type Article
Publisher Date 1968-06-25
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 21
Issue Number 6
Page Count 3
Starting Page 421
Ending Page 423


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