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Author Rohr, Jurgen ♦ Eick, Susanne ♦ Zeeck, Axel ♦ Reuschenbach, Peter ♦ Zähner, Hans ♦ Fiedler, HANS-PETER
Source J-STAGE
Content type Text
Publisher JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Language English
Abstract Tetracenomycins $B_{3}$ and $D_{3},$ besides tetracenomycin D $(D_{1}),$ were produced by a blocked mutant of the elloramycin producer Streptomyces olivaceus TÜ 2353. The compounds were isolated as red powders, and their structures were elucidated by comparing their physicochemical data with those of the known tetracenomycins $A_{2},$ $B_{1},$ $B_{2},$ D and E. Tetracenomycin $B_{3}$ (2), the main compound, and tetracenomycin D (3) were antibiotically inactive against Gram-positive and Gram-negative bacteria, whereas tetracenomycin $D_{3}$ (1) showed a moderate activity against Bacillus subtilis and Arthrobacter aurescens. Tetracenomycin $B_{3}$ (2) is the key intermediate where the biosynthesis of the elloramycins branches off from the line leading to tetracenomycin C (5) as the final product of the tetracenomycin biosynthesis branch.
ISSN 00218820
Learning Resource Type Article
Publisher Date 1988-08-25
e-ISSN 18811469
Journal The Journal of Antibiotics(antibiotics1968)
Volume Number 41
Issue Number 8
Page Count 8
Starting Page 1066
Ending Page 1073


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